"You put 2 and 2 together and come up with 16!"
(accusation)
If the question was mathematical then it doesn't provide all the details. To arrive at the conclusion and working mathematically, the simplest solution would be: 2 x 4 + 2 x 4 = 16
Working backwards -> why would 16 be the answer?
Perhaps more importantly, why would 2 x < more something or less > equal 16?
What's significant about the number 16?